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  • Title: Altered mRNA cap recognition activity of initiation factor 4E in the yeast cell cycle division mutant cdc33.
    Author: Altmann M, Trachsel H.
    Journal: Nucleic Acids Res; 1989 Aug 11; 17(15):5923-31. PubMed ID: 2671936.
    Abstract:
    The mutation in the S. cerevisiae cell cycle division mutant cdc33 consists of a single G to A transition in the open reading frame encoding translation initiation factor 4E (eIF-4E). This leads to the substitution of glycine 113 by aspartic acid close to tryptophane 115 in the protein. This mutation reduces cap binding activity of eIF-4E as measured by binding of eIF-4E to m7GDP agarose columns and slows down overall protein synthesis at the non-permissive temperature. Comparison of the cdc33 mutation with other mutations affecting eIF-4E function supports the view that tryptophane residues and their flanking regions are involved in cap binding activity of eIF-4E.
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