These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: GPCR profiling: from hits to leads and from genotype to phenotype.
    Author: Cvijic ME, Sum CS, Alt A, Zhang L.
    Journal: Drug Discov Today Technol; 2015 Nov; 18():30-7. PubMed ID: 26723890.
    Abstract:
    GPCRs remain one of the most important classes of drug targets and, therefore, GPCR assay development and high-throughput GPCR ligand profiling continue to be major efforts in drug discovery. This article focuses on GPCR platform strategies from hits to leads with miniaturized complex pharmacology approaches. Three main areas of GPCR profiling are discussed including pharmacologically relevant hit identification, the pharmacology dossier applied to parallel structure activity and structure liability relationships and high-throughput mechanism studies from genotype to phenotype.
    [Abstract] [Full Text] [Related] [New Search]