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  • Title: [The migration activity of blood leukocytes as an index of the immunologic status of a kidney allograft recipient].
    Author: Shabanova LN, Artemova AG, Sofronov BN.
    Journal: Urol Nefrol (Mosk); 1989; (3):53-7. PubMed ID: 2672530.
    Abstract:
    A total of 48 patients with chronic renal failure, 42 of them after allotransplantation of cadaveric kidney, were studied for leukocyte spontaneous migration and corresponding alterations in migration activity in the presence of renal antigens reflecting recipient sensitivity towards organospecific renal antigens. High levels of leukocyte spontaneous migrations and renal antigen sensitization were recorded in patients with acute course of renal transplant rejection versus those with no evidence of rejection or the persons with slowly progressing chronic rejection. It was stated that alterations in leukocyte migratory activity, both spontaneous and challenged by presence of renal antigen, could demonstrate the activity of immune processes in a recipient of renal transplant. The findings are of help in answering the question of how long the transplant could exist. Moreover, organospecific renal antigens are considered as possible participants, in line with transplantation antigens, in the mechanism of kidney rejection.
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