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  • Title: Two new secoiridoids and other anti-hepatitis B virus active constituents from Swertia patens.
    Author: He K, Geng CA, Cao TW, Wang HL, Ma YB, Zhang XM, Chen JJ.
    Journal: J Asian Nat Prod Res; 2016 Jun; 18(6):528-34. PubMed ID: 26727588.
    Abstract:
    Two new secoiridoids, swerpatic acid (1) with an unusual C8 skeleton and swerpalactone (2), were isolated along with ten known compounds (3-12) from the whole plants of Swertia patens. Their structures were elucidated by comprehensive spectroscopic analyses. Eight compounds were evaluated for their anti-hepatitis B virus (HBV) activities on Hep G 2.2.15 cell line in vitro. Compounds 4 and 10 showed moderate inhibitory activities on the secretion of HBsAg with IC50 values of 1.96 and 0.50 mM.
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