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  • Title: Osteogenic sarcoma in a patient with aplastic anemia.
    Author: Lascari AD, Eveloff AR.
    Journal: South Med J; 1977 Jul; 70(7):874-5. PubMed ID: 267329.
    Abstract:
    Osteogenic sarcoma developed in a 14-year-old boy 13 years after he had partially recovered from chloramphenicol-induced aplastic anemia. A possible relationship is considered between aplastic anemia, chloramphenicol, testosterone, prednisone, and osteogenic sarcoma. Leukemia has been reported following chloramphenicol-induced aplastic anemia and liver tumors have been associated with testosterone therapy. Certain chemicals have caused osteogenic sarcoma in animals. Thus, we believe there are sufficient a priori reasons to question an etiologic relationship between the cause or treatment of aplastic anemia and osteogenic sarcoma.
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