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  • Title: Effect of serum from diabetes-prone BB/OK rats on neonatal rat pancreatic islets and islet cell suspensions.
    Author: Schröder D, Hehmke B, Klöting I, Besch W.
    Journal: Exp Clin Endocrinol; 1989 May; 93(2-3):187-92. PubMed ID: 2673813.
    Abstract:
    Humoral-mediated cytolytic activity against neonatal rat pancreatic islet cells as well as islets of Langerhans was detected in sera of newly diagnosed diabetic BB/OK rats by measurement of enhanced 51Cr-release or insulin leakage. Beta-cell-specific functions of islet cell suspensions such as insulin secretion and (pro)insulin biosynthesis can be affected by BB rat serum in vitro.
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