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  • Title: The effect of cyclosporin A on the endocrine pancreas of rats.
    Author: Jablenska R.
    Journal: Exp Clin Endocrinol; 1989 May; 93(2-3):208-12. PubMed ID: 2673815.
    Abstract:
    Treatment with the immunosuppressive agent Cyclosporin A frequently gives rise to alteration of function in the Langerhans islet which may result in diabetes. Light microscopy, immunocytochemical, and electron microscopic investigations demonstrate degranulation and vacuolization of B endocrine pancreatic cells in treated animals. Similar changes, but to a milder degree, are observed in the A-cells. The morphological alterations described are likely to result from an inhibition of the synthesis and secretion of B-cells.
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