These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Role of insulin resistance and β cell function in the development of newly diagnosed type 2 diabetes].
    Author: Chen X, Su M, Wang C, Wu Z, Li S, Ying X, Wei G, Fu C, Jiang Q.
    Journal: Wei Sheng Yan Jiu; 2015 Nov; 44(6):881-6. PubMed ID: 26738376.
    Abstract:
    OBJECTIVE: To assess the possible role of insulin resistance (IR) and β cell function in the pathophysiology of newly diagnosed type 2 diabetics (T2DM). METHODS: An oral glucose tolerance test was obtained at the health cohort baseline. Subjects with normal glucose tolerance (NGT, n = 269), impaired glucose regulation (IGR, n = 269) and newly diagnosed type 2 diabetics (T2DM, n = 269) were defined by ADA criteria. Subjects with NGT and IGR were selected from residents living in the same community of diabetic patients with the same gender and age (± 3 years old). The T2DM group was sub-classified as isolated fasting hyperglycemia (IFH), isolated post-challenge hyperglycemia (IPH) and combined hyperglycemia (CH). The IGR group was sub-classified as impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and combined glucose intolerance (CGI). Homeostasis model assessment of insulin resistance (HOMA-IR), β cell function (HOMA-β) and deposition index (DI) were to evaluate the insulin resistance or sensitivity, islet β cell function and that when insulin compensated respectively. RESULTS: From NGT to T2DM, HOMA-IR increased while HOMA-β and DI decreased significantly (P < 0.05). After the adjustment of age, gender, obesity and hypertension, IFG and CGI subgroup had statistically higher HOMA-IR and lower HOMA-β and DI, and IGT subgroup only had lower HOMA-β and DI than NGT subgroup (P < 0.05). Compared to IGT subgroup, IFG and CGI subgroup had significantly higher HOMA-IR and lower HOMA-β and DI (P < 0.05). IFH and CH subgroup had statistically higher HOMA-IR and lower HOMA-β and DI than IFH subgroup (P < 0.05), DI of CH subgroup significantly decreased than that of IPH subgroup (P < 0.05). IFH and CH subgroup had statistically higher HOMA-IR and lower HOMA-β and DI than IFG and CGI subgroup respectively. HOMA-β and DI decreased of IPH subgroup compared to IGT subgroup, and multiple linear regression analysis showed that HOMA-IR had significant influence on fasting plasma glucose (FPG) in NGT (P < 0.05), whereas two-hour plasma glucose and FPG were influenced by DI (P < 0.05) in the progression. CONCLUSIONS: Both basic β cell dysfunction and IR exist in IFG and CGI, while only basic β cell dysfunction exist in IGT. The basic β cell dysfunction and IR are the primary features of fasting hyperglycemia, and basic β cell dysfunction also contribute to post- challenge hyperglycemia.
    [Abstract] [Full Text] [Related] [New Search]