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  • Title: Methotrexate pharmacokinetics in patients with rheumatoid arthritis.
    Author: Sinnett MJ, Groff GD, Raddatz DA, Franck WA, Bertino JS.
    Journal: J Rheumatol; 1989 Jun; 16(6):745-8. PubMed ID: 2674426.
    Abstract:
    Few studies have evaluated the pharmacokinetics of low dose oral methotrexate (MTX) therapy. MTX pharmacokinetics were studied in 10 patients with classic rheumatoid arthritis (RA) after a single 7.5 mg oral dose. MTX was rapidly absorbed. Peak concentrations varied considerably, ranging from 0.31-0.72 microM. Measurable drug concentration was found in all patients at 24 h after the dose. CL/F-MTX = 145 +/- 52 ml/min/1.73 m2 and elimination half-life was 4.5 +/- 0.89 h. Oral MTX given as a single weekly dose has predictable pharmacokinetics. Further studies to examine what relationship exists, if any, with efficacy and toxicity of MTX in RA must be undertaken.
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