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  • Title: IGF-1 is associated with fetal growth and preterm delivery in type 1 diabetic pregnancy.
    Author: Lauszus FF, Fuglsang J.
    Journal: Gynecol Endocrinol; 2016 Jun; 32(6):488-91. PubMed ID: 26758936.
    Abstract:
    AIM: No data on IGF-1 and either preterm or preeclampsia have been reported so far in diabetic pregnancies. We evaluated consecutive measurements of IGF-1 for preeclampsia, preterm delivery and birth weight in type 1 diabetic pregnancy. SETTING: In an outpatient university clinic, 97 pregnant women were consecutively recruited for evaluation of indicators for deterioration of diabetes status and adverse perinatal outcome. At every visit, a blood sample for measurement of IGF-1 was drawn. RESULTS: IGF-1 levels from week 14 to 32 was consistently lower in women who delivered preterm compared with women whose delivered after gestational week 36; the increase in 2nd and 3rd trimester was steeper in those delivering at term than in women delivering preterm (p = 0.032). IGF-1 in preeclampsia did not show the same relation in diabetic women (p = 0.74). The lowest tertile of birth weight ratio (0.8-1.2) was associated with lower IGF-1 from week 14 to 32 (p = 0.047, adjusted for preterm delivery and preeclampsia). CONCLUSION: We found low IGF-1 levels associated with preterm delivery and low birth weight.
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