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  • Title: [Thiotriazoline in the Treatment of Stable Angina Pectoris of II-III Functional Class].
    Author: Kadin DV, Chumak BA, Filippov AE, Shustov SB.
    Journal: Kardiologiia; 2015; 55(8):26-9. PubMed ID: 26761968.
    Abstract:
    Trimetazidine is a metabolic agent of proven efficacy in improving myocardial ischemia and angina. A comparative international multicenter randomized trial, assessed anti-anginal anti ischemic efficacy and safety of Trimetazidine (60 mg/d) and Thiotriazoline (600 mg/d) in symptomatic patients with chronic ischemic heart disease receiving the first line therapy. The study assessed the efficacy of the two drugs on total exercise duration, time to 1-mm ST segment depression, the number of angina attacks and nitroglycerin tablets consumed amount. Both drugs have demonstrated clinical efficacy equal for all primary and secondary endpoints.
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