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  • Title: Treatment of imipramine-resistant recurrent depression: I. An open clinical trial of adjunctive L-triiodothyronine.
    Author: Thase ME, Kupfer DJ, Jarrett DB.
    Journal: J Clin Psychiatry; 1989 Oct; 50(10):385-8. PubMed ID: 2676995.
    Abstract:
    Prior studies suggest that supplemental treatment with thyroid hormone may enhance the patient's response in depression resistant to tricyclic antidepressants. The authors report on the lack of efficacy of adjunctive L-triiodothyronine (T3; 25 micrograms/day) in a sample of 20 outpatient unipolar depressives who had not responded to greater than or equal to 12 weeks of treatment with imipramine (mean dosage = 240 mg/day) and interpersonal psychotherapy. The overall response rate after 4 weeks of T3 was low (25%); the outcome did not differ significantly from a matched historical comparison group who received continued tricyclic treatment but not T3.
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