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  • Title: Pulmonary artery aneurysms in Behçet's disease treated with anti-TNFα: A case series and review of the literature.
    Author: Chan E, Sangle SR, Coghlan JG, D'Cruz DD.
    Journal: Autoimmun Rev; 2016 Apr; 15(4):375-8. PubMed ID: 26777307.
    Abstract:
    Behçet's disease (BD) is a systemic inflammatory disorder of unknown aetiology. Pulmonary haemorrhage from ruptured pulmonary artery aneurysms (PAA) in this condition carries a high mortality but treatment has largely been empiric with use of glucocorticoids and cyclophosphamide. Tumour necrosis factor α (TNF-α) was recently recognised as a mediator in the pathogenesis of BD inflammatory lesions. TNFα inhibitors have been shown in various case reports/series to have beneficial effects in uveoretinitis, entero-Behçet's, neuro-Behçet's and BD arthritis. We describe the efficacy and tolerability of infliximab in 2 patients with Behçet's disease complicated by pulmonary vasculitis admitted to our unit during the years 2004-2015, and discuss the previously published data in this area.
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