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  • Title: Near-Infrared Image Reconstruction of Newborns' Brains: Robustness to Perturbations of the Source/Detector Location.
    Author: Ahnen L, Wolf M, Hagmann C, Sanchez S.
    Journal: Adv Exp Med Biol; 2016; 876():377-382. PubMed ID: 26782235.
    Abstract:
    The brain of preterm infants is the most vulnerable organ and can be severely injured by cerebral ischemia. We are working on a near-infrared imager to early detect cerebral ischemia. During imaging of the brain, movements of the newborn infants are inevitable and the near-infrared sensor has to be able to function on irregular geometries. Our aim is to determine the robustness of the near-infrared image reconstruction to small variations of the source and detector locations. In analytical and numerical simulations, the error estimations for a homogeneous medium agree well. The worst case estimates of errors in reduced scattering and absorption coefficient for distances of r=40 mm are acceptable for a single source-detector pair. The optical properties of an inhomogeneity representing an ischemia are reconstructed correctly within a homogeneous medium, if the error in placement is random.
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