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  • Title: Changes in prostaglandin renal synthesis in cardiovascular disease.
    Author: Fontana F, Guardigli G, Ruffini M, Chiarella M, Spagnolo N, de Collibus C, Bastagli L, Bernardi P.
    Journal: Riv Eur Sci Med Farmacol; 1989 Apr; 11(2):129-36. PubMed ID: 2678307.
    Abstract:
    We investigated the factors able to stimulate (hormones, drugs, fluid volume changes and prostaglandin precursors) or inhibit (NSAIDs) renal prostaglandin synthesis. We then assessed the effects of NSAIDs on: A) the efficacy of certain drugs (furosemide, ACE-inhibitors), whose action is mediated by a stimulation of prostaglandin synthesis; B) the physiopathology of cardiovascular diseases such as myocardial infarction and heart failure, in which renal and circulatory output is reduced; C) arterial hypertension.
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