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  • Title: Colorimetric determination of nadolol in tablets.
    Author: Ivashikiv E.
    Journal: J Pharm Sci; 1978 Jul; 67(7):1024-5. PubMed ID: 26790.
    Abstract:
    Nadolol was extracted from tablet excipients with an acidic potassium chloride solution. The drug was oxidized with periodic acid, and the resulting aldehyde was reacted with 2,4-dinitrophenylhydrazine to form the corresponding hydrazone. Excess reagent was removed with a cupric chloride solution. The hydrazone was extracted into chloroform, and its absorbance was measured at the 352-nm maximum.
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