These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The correlation between HLA-DR or CD38 expression in CD8(+)T cells and CD4(+)T cells count in treatment-naive HIV/AIDS patients].
    Author: Xie J, Qiu Z, Han Y, Li Y, Song X, Li T.
    Journal: Zhonghua Nei Ke Za Zhi; 2016 Jan; 55(1):36-9. PubMed ID: 26796651.
    Abstract:
    OBJECTIVE: To analyze the correlation between CD4(+)T cell count and HLA-DR or CD38 expression on peripheral CD8(+)T cells in treatment-naive Chinese HIV/AIDS patients. METHODS: A total of 471 treatment-naive HIV-infected patients and 53 healthy volunteers were enrolled. HLA-DR or CD38 expression on peripheral CD8(+)T cells, CD4(+)T cell count, naive CD4(+)T cell subsets and CD28 expression on T cells were measured by flow cytometry. Plasma HIV RNA load was quantified by real-time PCR (COBAS TaqMan RT-PCR). Mann-Whitney U test and Spearman's rank correlation test were used for statistical analysis. RESULTS: CD38 expression intensity on CD8(+)T cells was negatively correlated with CD4(+)T cell count (r = -0.53, P < 0.001) and naive CD4(+)T cell count (r = -0.48, P < 0.001). CD38 expression on CD8(+)T cells also displayed significantly negative correlation with CD28 expression on CD8(+)T cells (r = -0.46, P < 0.001). HLA-DR expression on CD8(+)T cells did not show significant correlation with CD4(+)T cell count. Only weak positive correlation was found between CD38 intensity on CD8(+)T cells and plasma HIV RNA load. CONCLUSIONS: Compared with HLA-DR, CD38 expression on CD8(+)T cells shows more significant negative correlation with CD4(+)T cell count in treatment-naive patients. CD38 and HLA-DR may play different roles on the persistent immune activation in HIV infection.
    [Abstract] [Full Text] [Related] [New Search]