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  • Title: [Morphological changes of pancreatic B cells in ventromedial hypothalamic (VMH)-lesioned obese rats].
    Author: Miyamoto Y, Miyamoto H, Sato E.
    Journal: Jikken Dobutsu; 1989 Oct; 38(4):319-25. PubMed ID: 2680530.
    Abstract:
    Morphological changes of pancreatic B cells were investigated in ventromedial hypothalamic (VMH)-lesioned obese rats. An increase in body weight, a decrease in body length, and a marked increase in fat-pad were observed in VMH-lesioned obese rats. The volume density of pancreatic islets and that of B cells in VMH-lesioned obese rats were more increased than those in sham-operated control rats. The B cells of VMH-lesioned obese rats often showed a slight reaction for aldehyde fuchsin or anti-pig insulin serum. By the electron microscopy, the degranulated B cells were found to contain well developed Golgi apparatus and rough endoplasmic reticulum. These observations indicate increased activities of synthesis and release of insulin. We concluded that VMH-lesioned obesity was caused by accelerated lipogenesis with hypersecretion of insulin.
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