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  • Title: Spectrum of Choroidal Involvement in Presumed Ocular Tuberculosis: Report from a Population with Low Endemic Setting for Tuberculosis.
    Author: Agrawal R, Gupta B, González-López JJ, Cardoso J, Triantafullopoulou I, Grant R, Addison PK, Westcott M, Pavesio CE.
    Journal: Ocul Immunol Inflamm; 2017 Feb; 25(1):97-104. PubMed ID: 26807675.
    Abstract:
    OBJECTIVE: To describe the clinical spectrum and outcome of patients with presumed tubercular uveitis and choroidal involvement. METHODS: A retrospective case series nested in a cohort study was enrolled at a tertiary referral eye care center in the UK. Failure was defined as recurrence of lesion within 6 months of completion of antitubercular therapy (ATT) or corticosteroid therapy. RESULTS: Seventy-seven patients with presumed ocular tuberculosis and choroidal involvement were included in the study. Mean age was 45.5 ± 15.7 years, 44 (57.1%) patients were male, and 51 (66.2%) presented with bilateral disease. Choroidal granuloma was the most frequent clinical presentation (n = 27, 35.07%), followed by multifocal choroiditis (n = 24, 31.17%) and serpiginous-like choroiditis (n = 18, 23.38%). Quantiferon Gold in Tube Test (QFT) was positive in 64 (83.11%) patients. Fifty (64.94%) patients received ATT. CONCLUSIONS: Choroidal involvement in presumed ocular tuberculosis can present with a variable spectrum. Treatment failure rates were equivalent between ATT and non-ATT treated groups.
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