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  • Title: The penetration of aztreonam, a monobactam antibiotic, into intra-abdominal abscesses.
    Author: Youngs DJ, Burdon DW, Keighley MR.
    Journal: J Antimicrob Chemother; 1989 Sep; 24(3):425-9. PubMed ID: 2681121.
    Abstract:
    We have studied the penetration of aztreonam into pus with a low mortality intra-abdominal abscess model in the Wistar rat. The mean peak serum concentration (standard error) of aztreonam was 74.6 +/- 9.88 mg/l at 30 min falling to 2.31 +/- 1.28 mg/l at 8 h. The mean concentration in pus was 17.04 +/- 2.01 mg/l at 2 h and was 14.47 +/- 2.23 mg/l at 8 h. These concentrations are in excess of the MICs of most Gram-negative aerobic bacilli commonly isolated from intra-abdominal abscesses.
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