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  • Title: [Analysis of pancreatic enzymes in the bile of congenital choledochal cyst with anomalous pancreaticobiliary ductal union].
    Author: Shibata T, Hayakawa T, Kondo T, Kitagawa M, Sakai Y, Ono H, Kiriyama S, Nimura Y, Hayakawa N, Kamiya J.
    Journal: Nihon Shokakibyo Gakkai Zasshi; 1989 Jul; 86(7):1513-8. PubMed ID: 2681892.
    Abstract:
    Pancreatic enzymes in the bile of congenital choledochal cyst with anomalous pancreaticobiliary ductal union were analyzed. Almost all pancreatic proteases were already activated in the bile aspirated immediately after insertion of PTCD tube. However, inactive proteases gradually increased after continuation of drainage by PTCD. Pancreatic protease activities appeared again after clamping the PTCD tube. In vitro study of trypsin activities in the bile containing no initial trypsin activity, active type of trypsin did not appear throughout the experimental period. It is suggested that continuous reflux of pancreatic juice into the bile and certain incubation time are necessary for activation of pancreatic protease in bile of congenital choledochal cyst.
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