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  • Title: Myocardial injury and acute renal failure associated with lactic acidosis due to suicide attempt with metformin.
    Author: Sertbas M, Sertbas Y, Ordu O, Berber E, Ozen B, Ozdemir A.
    Journal: J Pak Med Assoc; 2016 Feb; 66(2):223-5. PubMed ID: 26819175.
    Abstract:
    Metformin-associated lactic acidosis (MALA) is one of the most important drug toxicities with a high morbidity and mortality rate. We report herein a case of suicide attempt with metformin presenting as MALA and acute renal failure on admission to emergency department and acute myocardial injury later on hospitalisation. An obvious improvement of metabolic parameters was seen in our patient provided by anti-ischaemic treatment together with bicarbonate infusion and haemodialysis. Although myocardial injury due to MALA is not a common disorder, we must be aware that metformin overdose with lack of tissue oxygenation, hypoperfusion, and arrhythmias may cause myocardial ischaemia.
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