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  • Title: Adverse effects of a proposed equine sublethal endotoxin model.
    Author: Stadler P, Van Amstel SR.
    Journal: Onderstepoort J Vet Res; 1989 Sep; 56(3):207-9. PubMed ID: 2682422.
    Abstract:
    Commercially available Escherichia coli 055: B5 lipopolysaccharide was administered intravenously experimentally at a dosage of 10 micrograms/kg to 2 horses. Various clinical and clinico-pathological parameters were monitored before and after the endotoxin administration. Because of a hopeless prognosis, and for humane reasons, euthanasia was applied on both horses 6 h after administration. Values recorded for the different parameters, including the blood lactate level, were consistent with a lethal condition. It would appear that an intravenous dose of 10 micrograms/kg of endotoxin is potentially lethal to horses.
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