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  • Title: Perioperative ROTEM and ROTEMplatelet monitoring in a case of Glanzmann's thrombasthenia.
    Author: Grassetto A, Fullin G, Lazzari F, Panizzo F, Polese F, Gessoni G, Farnia A.
    Journal: Blood Coagul Fibrinolysis; 2017 Jan; 28(1):96-99. PubMed ID: 26825624.
    Abstract:
    Glanzmann's thrombasthenia is a rare, inherited disease, which consists in abnormality of the glycoprotein IIa/IIIb genes that causes impaired platelet function. Glanzmann's thrombasthenia patients show prolongation of bleeding time and may experience life-threatening hemorrhage after surgery. We present a case of a young woman having Glanzmann's thrombasthenia, who underwent gynecological operation for ovarian cyst. Perioperative monitoring included thromboelastometry with ROTEM and impedance aggregometry with ROTEMplatelet. In this case, despite acceptable ROTEM results after platelet transfusion, ROTEMplatelet was more indicative of hemostatic impairment and reflected the bleeding occurred in the postoperative period. When treating patients with congenital or acquired platelet dysfunction, some intrinsic limits of thromboelastometry to assess platelet function may be overcome with the combined use of a point-of-care device that measures platelet aggregation.
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