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  • Title: A t(11;14)(p13;q11.2) in myelofibrosis following polycythemia vera.
    Author: Jeong JH, Ahn JY, Park PW, Seo YH, Seo JY, Lee JH, Kim KH.
    Journal: Cancer Genet; 2016 Mar; 209(3):112-6. PubMed ID: 26826764.
    Abstract:
    Chromosomal abnormalities at 14q11, which encodes the T-cell receptor α and δ chain genes, are generally specific for T-cell malignancies, and are rarely reported in other malignancies. We report a novel t(11;14)(p13;q11.2) in a patient with myelofibrosis (MF) following polycythemia vera (PV). This 55-year-old male developed post-PV MF 12 years after the initial diagnosis of PV. He had a normal karyotype at polycythemic disease stage, t(11;14)(p13;q11.2) was newly detected at the time of fibrotic transformation. Therefore, it is likely that this clonal chromosomal abnormality was associated with progression of disease.
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