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  • Title: Sulfated polysaccharide isolated from the sea cucumber Stichopus japonicas promotes the SDF-1α/CXCR4 axis-induced NSC migration via the PI3K/Akt/FOXO3a, ERK/MAPK, and NF-κB signaling pathways.
    Author: Cui C, Wang P, Cui N, Song S, Liang H, Ji A.
    Journal: Neurosci Lett; 2016 Mar 11; 616():57-64. PubMed ID: 26827717.
    Abstract:
    The present study describes a positive regulatory loop between SJP and the SDF-1α/CXCR4 axis in NSC migration. The treatment of NSCs with SJP and SDF-1α increases the cell migration capacity and promotes cell migration from the neurospheres. These effects are accompanied by the up-regulation of Nestin, N-cadherin, TLR4, TNF-α, Cyclin D1, EGFR, Alpha 6 integrin, MMP-2, MMP-9, and iNOS, including SDF-1α and CXCR4 themselves. However, these effects are blocked by AMD3100, LY294002, U0126, and PDTC. SJP enhances the SDF-1α/CXCR4 axis-induced MMP-2 and MMP-9 secretion and NO release. Results demonstrate that interaction of SJP with the SDF-1α/CXCR4 axis regulates NSC migration via the PI3K/Akt/FOXO3a, ERK-MAPK, and NF-κB signaling pathways.
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