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  • Title: [Clinical significance of detecting t(11;14) by fluorescence in situ hybridization for the diagnosis of 7 patients with atypical mantle cell lymphoma].
    Author: Zhu J, Wu Z, Fan L, Xu W, Li J.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2016 Feb; 33(1):13-6. PubMed ID: 26829725.
    Abstract:
    OBJECTIVE: To study the clinical features and diagnosis of 7 patients with atypical mantle cell lymphoma (MCL). METHODS: The 7 MCL patients were misdiagnosed as chronic lymphocytic leukemia (CLL) due to a score of 4 for their immunophenotypes. The clinical features and diagnosis of such patients were retrospectively analyzed. RESULTS: Six patients had superficial lymphadenectasis but their lymph nodes could not be palpated. All 7 patients were as stage IV considering bone marrow infiltration. Scores of immunophenotype of CLL were 4, and interphase fluorescence in situ hybridization (FISH) for t(11;14) were positive in all patients. CONCLUSION: Some MCL patients have clinical features similar to CLL. Interphase FISH can play an important role in the diagnosis of MCL.
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