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  • Title: Two new phragmalin-type limonoids from Chukrasia tabularis and their α-glucosidase inhibitory activity.
    Author: Peng JL, Wang J, Mei WL, Kong FD, Liu ZQ, Wang P, Gai CJ, Jiang B, Dai HF.
    Journal: J Asian Nat Prod Res; 2016 Jul; 18(7):629-36. PubMed ID: 26837821.
    Abstract:
    Phytochemical investigation on the stems of C. tabularis (Meliaceae) led to the isolation of two new phragmalin-type limonoids, named tabularisins S and T (1-2), along with five known ones (3-7). The structures of the new limonoids were established by spectroscopic methods including UV, IR, HRESIMS, and 1D and 2D NMR. All the compounds were evaluated for α-glucosidase inhibitory activity in vitro. Compounds 2 and 3 exhibited significant inhibitory activity against α-glucosidase with IC50 values of 0.15 and 0.03 mM, respectively (acarbose as positive control, IC50 0.95 mM).
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