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  • Title: Carbohydrate gel ingestion during running in the heat on markers of gastrointestinal distress.
    Author: Sessions J, Bourbeau K, Rosinski M, Szczygiel T, Nelson R, Sharma N, Zuhl M.
    Journal: Eur J Sport Sci; 2016 Nov; 16(8):1064-72. PubMed ID: 26841003.
    Abstract:
    UNLABELLED: The purpose of this study is to measure the effects of carbohydrate ingestion during exercise in the heat by measuring markers of gastrointestinal damage and inflammation. METHODS: Active subjects (n = 7) completed two 60-min running trials in a heated environment (70% VO2max, 30°C). At minute 20 of exercise, subjects consumed a carbohydrate gel (Cho) (27 g), or a non-carbohydrate placebo (nCho). Plasma endotoxin, I-FABP, TNF-α, IL-6, IL-1β, IL-10, and MCP-1 were measured pre-exercise, 20-min post-exercise, and again 2-h, and 4-h post-exercise. RESULTS: Endotoxin increased 20-min post-exercise compared to pre in the Cho trial only (p = .03). I-FABP levels increased 20-min post-exercise in the Cho trial only compared to pre-exercise (p = .003). I-FABP levels were also increased in Cho trial 20-min post-exercise when compared to same time point in the nCho trial (p = .032). TNF-α increased 20-min post-exercise in the Cho trial only compared to pre (p = .03). Plasma IL-6 concentration increased 20-min post-exercise when compared to pre in both the Cho (p = .002) and nCho (p = .009), but remained elevated at the 2-h time point in the nCho trial (p = .03). I-FABP and several plasma cytokines (TNF-α, MCP-1, Il-6) returned to baseline sooner in the Cho trial. CONCLUSIONS: Ingestion of carbohydrate gel during exercise in the heat enhances markers of gastrointestinal wall damage.
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