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  • Title: Immunohistologic demonstration of type II collagen in synovial fluid phagocytes of osteoarthritis and rheumatoid arthritis patients.
    Author: Moreland LW, Stewart T, Gay RE, Huang GQ, McGee N, Gay S.
    Journal: Arthritis Rheum; 1989 Nov; 32(11):1458-64. PubMed ID: 2684170.
    Abstract:
    We were able to demonstrate type II collagen in synovial phagocytes of osteoarthritis (OA) and rheumatoid arthritis (RA) patients, using a monoclonal antibody to human type II collagen and immunoperoxidase staining. In addition, using immunoelectron microscopy, we demonstrated labeled fragments in synovial phagocytes of both RA and OA patients. This immunohistochemical assay may prove to be a sensitive indicator of cartilage erosion in patients with OA and RA.
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