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  • Title: Case Report of an Hepatoid Adenocarcinoma of the Stomach.
    Author: Gaeta R, Ugolini C, Castagna M.
    Journal: Appl Immunohistochem Mol Morphol; 2016 Feb; 24(2):e6-8. PubMed ID: 26844385.
    Abstract:
    Hepatoid adenocarcinoma (HAC) is a rare but important type of extrahepatic tumor that has a morphologic similarity to hepatocellular carcinoma, with production of α-fetoprotein in high amounts and a poor prognosis. Stomach is one of the organs in which HAC has been most commonly identified. We report a case of an old man with a polypoid mass in the prepyloric region. The microscopical aspects were suggestive for an undifferentiated adenocarcinoma, but the positive immunohistochemical staining for α-fetoprotein, α-1-antitrypsin, α-1-antichymotrypsin, and Hep Par1 were crucial for the final diagnosis of hepatoid adenocarcinoma of the stomach. Because of the poor prognosis for this type of tumor, correct and early-stage diagnosis of HAC is essential and long-term follow-up is required.
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