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Title: Substrate-Controlled, One-Pot Synthesis: Access to Chiral Chroman-2-one and Polycyclic Derivatives. Author: Sun XL, Chen YH, Zhu DY, Zhang Y, Liu YK. Journal: Org Lett; 2016 Feb 19; 18(4):864-7. PubMed ID: 26844950. Abstract: Based on the appropriate choice of electrophiles, one-pot, multicomponent, enantioselective domino reactions have been realized which contain a five-step sequence and provide highly efficient access to potentially bioactive chroman-2-one derivatives as a single diastereoisomer with excellent enantioselectivities and in high yields. This new strategy could significantly improve the previous protocol by directly starting from commercial 2-hydroxybenzaldehydes rather than preformed lactols, which have to be synthesized in several additional steps.[Abstract] [Full Text] [Related] [New Search]