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  • Title: Gastrin-releasing peptide-like immunoreactivity in porcine follicular fluid and ovary.
    Author: Gnessi L, Altamura S, Arizzi M, Tei C, La Torre C, Bonifacio V, Facchinetti F, Spera G.
    Journal: Mol Cell Endocrinol; 1989 Sep; 66(1):115-8. PubMed ID: 2684704.
    Abstract:
    Porcine follicular fluid was found to contain gastrin-releasing peptide (GRP) by radioimmunoassay. High pressure liquid chromatography of the extracted material showed two peaks of GRP immunoreactivity that closely resembled the C-terminal fragments of GRP, GRP18-27 and GRP14-27. Immunohistochemical studies revealed specific staining for GRP in the granulosa cells of adult porcine ovary. These results demonstrate the presence of substances which behave like authentic GRP-like peptides in porcine ovary and follicular fluid and suggest that these peptides may play a paracrine and/or autocrine role in the regulation of the ovarian function.
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