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  • Title: Dendritic cells and scavenger macrophages in pancreatic islets of prediabetic BB rats.
    Author: Voorbij HA, Jeucken PH, Kabel PJ, De Haan M, Drexhage HA.
    Journal: Diabetes; 1989 Dec; 38(12):1623-9. PubMed ID: 2684715.
    Abstract:
    Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease whose notorious pathologic feature is insulitis accompanied by destruction of beta-cells. In this morphological study, we examined the pancreatic events during the onset of diabetes in spontaneously diabetic BB/Organon rats. Dendritic cells were the first cells to accumulate around the islets, followed by lymphocytes. Scavenger macrophages and MHC class II-positive beta-cells were only seen late in the disease. These observations suggest a role for antigen-presenting dendritic cells in the onset of the beta-cell-specific autoimmune reaction and emphasize the necessity to distinguish between the several monocyte-macrophage subtypes in studies on the pathogenesis of IDDM.
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