These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Acute vincristine neurotoxicity in the presence of hereditary motor and sensory neuropathy type I.
    Author: McGuire SA, Gospe SM, Dahl G.
    Journal: Med Pediatr Oncol; 1989; 17(6):520-3. PubMed ID: 2685529.
    Abstract:
    Acute vincristine neurotoxicity leading to a severe motor and sensory neuropathy has been noted in patients with hereditary motor and sensory neuropathy type I (HMSN-I). The case of a 2-year-old boy with acute lymphocytic leukemia and HMSN-I is reported, and additional cases from the literature are reviewed. Severe vincristine neurotoxicity in patients with HMSN-I may be secondary to impairment of both slow and- fast axonal transport. Vincristine should be used with caution in patients with a family history of polyneuropathy.
    [Abstract] [Full Text] [Related] [New Search]