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  • Title: B-cell acute lymphoblastic leukemia with mature phenotype and MLL rearrangement: report of five new cases and review of the literature.
    Author: Sajaroff EO, Mansini A, Rubio P, Alonso CN, Gallego MS, Coccé MC, Eandi-Eberle S, Bernasconi AR, Ampatzidou M, Paterakis G, Papadhimitriou SI, Petrikkos L, Papadakis V, Polychronopoulou S, Rossi JG, Felice MS.
    Journal: Leuk Lymphoma; 2016 Oct; 57(10):2289-97. PubMed ID: 26857438.
    Abstract:
    The association between mature-B phenotype and MLL abnormalities in acute lymphoblastic leukemia (ALL) is a very unusual finding; only 14 pediatric cases have been reported so far. We describe the clinical and biological characteristics and outcome of five pediatric cases of newly diagnosed B lineage ALL with MLL abnormalities and mature immunophenotype based on light chain restriction and surface Ig expression. Blasts showed variable expression of CD10/CD34/TdT. MLL abnormalities with no MYC involvement were detected in all patients by G-banding, FISH, and/or RT-PCR. Three patients were treated according to Interfant protocol, one to ALLIC-09, and one received B-NHL-BFM-2004. All patients achieved complete remission and three of them relapsed. Despite the small cohort size, it could be postulated that B lineage ALL with MLL abnormalities and mature phenotype is a distinct entity that differs both from the typical Pro B ALL observed in infants and mature B-ALL with high MYC expression.
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