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  • Title: IL-12Rβ2 has a protective role in relapsing-remitting experimental autoimmune encephalomyelitis.
    Author: Xie C, Ciric B, Yu S, Zhang GX, Rostami A.
    Journal: J Neuroimmunol; 2016 Feb 15; 291():59-69. PubMed ID: 26857496.
    Abstract:
    IL-12Rβ2 is a common receptor subunit of heterodimeric receptors for IL-12 and IL-35, two cytokines that are implicated in immunopathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. We evaluated the role of IL-12Rβ2 in relapsing-remitting EAE (RR-EAE). IL-12Rβ2-deficient SJL/J mice developed markedly more severe clinical EAE, and had greater mortality and more severe relapses compared with wild-type controls. IL-12Rβ2-deficient EAE mice also had more infiltrating mononuclear cells in the CNS, as well as higher T cell proliferative capacity and decreased IFN-γ production at the periphery. These findings demonstrate a protective role of IL-12Rβ2 in RR-EAE.
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