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  • Title: [Neurochemical perspectives of the function of monoamine oxidases].
    Author: Riederer P, Konradi C, Hebenstreit G.
    Journal: Psychiatr Prax; 1989 Aug; 16 Suppl 1():7-10. PubMed ID: 2685857.
    Abstract:
    Monoamine oxidase (MAO) and its subtypes MAO-A and MAO-B show different distribution in post mortem human brain areas. While MAO-B is the predominant type in glial tissue, intraneuronal MAO is either of type A (locus coeruleus, only 10% of substantia nigra neurons stain MAO-A), while raphe neurons contain entirely MAO-B. Inhibition of MAO-subtypes leads to accumulation of biogenic amines in glial tissue while there is a selective intraneuronal influence differing between various brain areas. Generation of toxic end-products (eg. aldehydes, hydrogen peroxide, ammonia) may contribute to trigger or at least to progress Parkinson's disease.
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