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  • Title: Intravoxel incoherent motion MR imaging for breast lesions: comparison and correlation with pharmacokinetic evaluation from dynamic contrast-enhanced MR imaging.
    Author: Liu C, Wang K, Chan Q, Liu Z, Zhang J, He H, Zhang S, Liang C.
    Journal: Eur Radiol; 2016 Nov; 26(11):3888-3898. PubMed ID: 26863896.
    Abstract:
    OBJECTIVES: To compare diagnostic performance for breast lesions by quantitative parameters derived from intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and to explore whether correlations exist between these parameters. METHODS: IVIM and DCE MRI were performed on a 1.5-T MRI scanner in patients with suspicious breast lesions. Thirty-six breast cancers and 23 benign lesions were included in the study. Quantitative parameters from IVIM (D, f and D*) and DCE MRI (Ktrans, Kep, Ve and Vp) were calculated and compared between malignant and benign lesions. Spearman correlation test was used to evaluate correlations between them. RESULTS: D, f, D* from IVIM and Ktrans, Kep, Vp from DCE MRI were statistically different between breast cancers and benign lesions (p < 0.05, respectively) and D demonstrated the largest area under the receiver-operating characteristic curve (AUC = 0.917) and had the highest specificity (83 %). The f value was moderately statistically correlated with Vp (r = 0.692) and had a poor correlation with Ktrans (r = 0.456). CONCLUSIONS: IVIM MRI is useful in the differentiation of breast lesions. Significant correlations were found between perfusion-related parameters from IVIM and DCE MRI. IVIM may be a useful adjunctive tool to standard MRI in diagnosing breast cancer. KEY POINTS: • IVIM provided diffusion as well as perfusion information • IVIM could help differential diagnosis of breast lesions • Correlations were found between perfusion-related parameters from IVIM and DCE MRI.
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