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  • Title: [Construction of a family of artificial genes of human insulin].
    Author: Efimov VA, Buriakova AA, Pashkova IN, Polushin NN, Chakhmakhcheva OG.
    Journal: Bioorg Khim; 1989 Aug; 15(8):1070-7. PubMed ID: 2686651.
    Abstract:
    Using oligonucleotide-directed mutagenesis and chemical-enzymatic DNA synthesis, genes for A and B insulin chains, C-peptide and Tyr-C-peptide have been constructed starting from synthetic gene for human proinsulin synthesized earlier. The genes for human preproinsulin, mini-proinsulin, single-chain insulin and their modifications were also synthesized. The constructions obtained were cloned in plasmid vectors.
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