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  • Title: Efficacy, safety, and tolerability of ioversol in intra-arterial digital subtraction angiography.
    Author: Miller FJ, Pollei SR, Osborn AG.
    Journal: Invest Radiol; 1989 Jun; 24 Suppl 1():S52-4. PubMed ID: 2687197.
    Abstract:
    Twenty-two women and 18 men undergoing intra-arterial digital subtraction angiography were enrolled in an open-label, noncomparative study to assess the efficacy, safety, and patient tolerance of the contrast medium ioversol. The quality of radiographs generated was excellent in 60.0% of the studies, diagnostic in 37.5%, and nondiagnostic in 2.5%. There were no clinically significant drug-related changes in vital signs or laboratory tests among the patients, and no drug-related adverse effects were reported. Heat and pain related to injection of ioversol were graded on a four-point scale, with 0 indicating none and 3 indicating severe. The average scores were 1.3 for heat and 0.1 for pain. In this study, ioversol was a safe and effective contrast medium for angiography and was associated with a low incidence of patient discomfort.
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