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  • Title: Ioversol clinical safety summary.
    Author: Benamor M, Aten EM, McElvany KD, Lankin DG, James MA, Buy-Gandal T, Harashe LT, Weinandt WJ.
    Journal: Invest Radiol; 1989 Jun; 24 Suppl 1():S67-72. PubMed ID: 2687200.
    Abstract:
    The authors evaluated double-blind comparative and open-label clinical trials in 1,186 patients who received ioversol to evaluate the safety and efficacy of ioversol, a new nonionic low-osmolality contrast medium, at iodine concentrations of 32%, 24%, and 16%. The results indicate that ioversol was well tolerated in all patients and showed fewer adverse effects than conventional ionic agents. The diagnostic efficacy of ioversol was comparable to both conventional and other nonionic agents with respect to diagnostic quality. However, the improved patient tolerance may contribute to higher quality radiographs. The effects on renal function were monitored at 24, 48, 72, and 96 hours and did not reveal any clinically or statistically significant changes.
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