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  • Title: Expression of nuclear lamins in mammalian somatic cells lacking cytoplasmic intermediate filament proteins.
    Author: Paulin-Levasseur M, Scherbarth A, Giese G, Röser K, Bohn W, Traub P.
    Journal: J Cell Sci; 1989 Mar; 92 ( Pt 3)():361-70. PubMed ID: 2687302.
    Abstract:
    Using immunofluorescence and immunoblotting techniques, we have examined the composition of the nuclear lamina in murine plasmacytoma cells, MPC-11, exposed to the phorbol ester TPA as well as in two cell lines devoid of cytoplasmic intermediate filament proteins, the human adrenal cortex carcinoma-derived cells SW-13 and the clone C6-M-D4 derived from the rat glial cell line C6. Our results show that the inhibition of proliferation and the induction of vimentin synthesis observed in TPA-treated MPC-11 populations are not paralleled by changes in the lamin complement of these cells, which contain lamin B but lack lamins A and C. Furthermore, the analysis performed on SW-13 and C6-M-D4 cell lines clearly demonstrates that mammalian somatic cells display considerable variations in lamin expression and indicates that lamin B may be the only lamin species constitutively expressed in mammalian cells.
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