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  • Title: C-myc-S mu rearrangement in a murine plasmacytoma without visible chromosomal translocations.
    Author: Ohno S, Migita S, Murakami S.
    Journal: Oncogene; 1989 Dec; 4(12):1513-7. PubMed ID: 2687771.
    Abstract:
    We report here that one murine plasmacytoma (DCPC 21) arising in a Balb/c mouse implanted i.p. with a Millipore diffusion chamber lacks any known chromosomal translocations. In situ molecular hybridization analysis of the metaphase spreads of DCPC 21, however, revealed that the c-myc gene has moved to the IgH locus on the chromosome 12. Further, an Ig switch region-mediated recombination was detected. The DNA sequencing analysis demonstrated that the c-myc gene has juxtaposed directly to S mu 5'-flanking sequence in a 'head-to-tail' orientation. The results strongly support our notion that the c-myc rearrangement is an essential step in the genesis of murine plasmacytomas, whether or not they have visible chromosomal translocations.
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