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  • Title: Lateralization of neocortical dopamine receptors and dopamine level in normal Wistar rats.
    Author: Nowak G.
    Journal: Pol J Pharmacol Pharm; 1989; 41(2):133-7. PubMed ID: 2687822.
    Abstract:
    A lateral asymmetry of dopamine receptors (D-1, D-2) and dopamine (DA) level was found in the left and right neocortices of male Wistar rats. The specific D-1 receptor binding (3H-SCH 23390) was by 24% (p less than 0.05), the specific D-2 receptor binding (3H-spiperone)----by 31% (0.1 greater than p greater than 0.05) and the DA level ---- by 80% higher (p less than 0.001) in the right than in the left neocortex. In the other examined brain regions (striatum and limbic system) no lateralization in D-1 or D-2 receptors was observed. The physiological significance of the neocortical lateralization (DA receptors and level) is unknown, yet it is important for experimental and methodological reasons.
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