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Title: Retinal optical coherence tomography at 1 μm with dynamic focus control and axial motion tracking. Author: Cua M, Lee S, Miao D, Ju MJ, Mackenzie PJ, Jian Y, Sarunic MV. Journal: J Biomed Opt; 2016 Feb; 21(2):26007. PubMed ID: 26882449. Abstract: High-resolution optical coherence tomography (OCT) retinal imaging is important to noninvasively visualize the various retinal structures to aid in better understanding of the pathogenesis of vision-robbing diseases. However, conventional OCT systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking OCT system with automatic focus optimization for high-resolution, extended-focal-range clinical retinal imaging by incorporating a variable-focus liquid lens into the sample arm optics. Retinal layer tracking and selection was performed using a graphics processing unit accelerated processing platform for focus optimization, providing real-time layer-specific en face visualization. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the retina and optic nerve head, from which we extracted clinically relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.[Abstract] [Full Text] [Related] [New Search]