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  • Title: MiR-204 inhibits the proliferation and invasion of renal cell carcinoma by inhibiting RAB22A expression.
    Author: Xiong F, Liu K, Zhang F, Sha K, Wang X, Guo X, Huang N.
    Journal: Oncol Rep; 2016 May; 35(5):3000-8. PubMed ID: 26883716.
    Abstract:
    While miR-204 expression may be linked to renal cell carcinoma (RCC) progression, the detailed mechanisms remain unclear. In the present study, we demonstrated that miR-204 was differentially expressed in RCC tissues when compared with surrounding normal kidney tissues. Ectopic overexpression of miR-204 in human RCC cells suppressed cell proliferation and invasion in vitro and in vivo. Mechanism dissection revealed that miR-204 may function through RAB22A signals to inhibit RCC proliferation and invasion. Overexpression of RAB22A by oe-RAB22A was able to partially reverse the miR-204-mediated suppression of RCC tumor progression. Together, these results revealed that miR-204 suppressed RCC proliferation and invasion by directly targeting the RAB22A gene. Targeting newly identified RAB22A with miR-204 may aid in the suppression of RCC proliferation and invasion.
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