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  • Title: Comparison of one dose cefazolin versus one dose cefotetan for cesarean section prophylaxis.
    Author: Probst JR, Benrubi GI, Sanchez-Ramos L, Todd M.
    Journal: J Fla Med Assoc; 1989 Dec; 76(12):1027-9. PubMed ID: 2689574.
    Abstract:
    During one year, 646 women who delivered by cesarean section entered into a prospective randomized clinical trial to determine if a single intraoperative dose of cefazolin was as effective as cefotetan in the prevention of postoperative endomyometritis. Of 336 patients receiving 2 gm cefazolin intravenously at the time of clamping of the cord, endomyometritis developed in 30 (8.91%), and of 310 patients who received 2 gm cefotetan intravenously at the time of clamping of the cord, endomyometritis developed in 36 (11.6%). There was no statistically significant difference in the incidence of endomyometritis between the two groups (p = .269). We conclude that since the two drugs are equal in efficacy 2 gm of cefazolin is a cost effective method of prophylaxis for cesarean section.
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