These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: An altered v-raf is required in addition to v-myc in J3V1 virus for acceleration of murine plasmacytomagenesis.
    Author: Troppmair J, Potter M, Wax JS, Rapp UR.
    Journal: Proc Natl Acad Sci U S A; 1989 Dec; 86(24):9941-5. PubMed ID: 2690079.
    Abstract:
    We have isolated and molecularly cloned a highly pathogenic virus variant, J3V1, from murine plasmacytomas induced by a combination of pristane and the weakly transforming recombinant retrovirus J3. J3 virus is a derivative of the v-raf/v-myc-carrying J2 virus that was generated by a frameshifting deletion inactivating v-raf in J2. J3V1 contains an additional deletion of 334 base paris in gag, which restores the correct reading frame for v-raf and results in the expression of a p57 gag-raf fusion protein. Reactivation of v-raf in J3 is required for efficient plasmacytoma acceleration in pristane-conditioned BALB/cAn mice.
    [Abstract] [Full Text] [Related] [New Search]