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  • Title: Rapidly Progressive Transthyretin-Mediated Amyloidosis in a Domino Liver Transplant Recipient of a Ser23Asn Donor.
    Author: Dixit N, Castano A, Farr MJ, Traub R, Lentzsch S, Brown RS, Maurer MS, Brannagan TH.
    Journal: J Clin Neuromuscul Dis; 2016 Mar; 17(3):142-5. PubMed ID: 26905915.
    Abstract:
    Domino liver transplantation, in which the liver of a patient with transthyretin-mediated amyloidosis is transplanted into another patient, has been an established procedure performed at several centers across the world. The risk of developing systemic amyloidosis in transthyretin-mediated amyloidosis liver transplant recipients is a topic of ongoing investigation. We report a case of rapidly progressive transthyretin amyloidosis in a patient who received a liver from a donor with a rare Ser23Asn mutation. We advise exercising caution when considering domino liver transplantation in patients with this particular mutation.
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